Be Aware of the Dangers of Serotonin Syndrome


Serotonin is a hormone, also known as 5-hydroxytryptamine or 5-HTP, found in the body. Primary centers containing this hormone are the brain, pineal gland, blood platelets and the intestines. Serotonin is formed in the body from L-tryptophan, an amino acid. The body then stores serotonin until it is activated by the enzyme monoamine oxidase. Serotonin is a neurotransmitter, meaning that it is responsible for transmitting messages or signals between nerve cells, causing a narrowing of the blood vessels.

Serotonin plays a major role in several important bodily functions, such as appetite and sleep. It is also known for the role it plays in regulating mood, learning, memory and behavior. Serotonin plays an important role in cardiovascular function, temperature regulation, endocrine regulation and muscle retraction. Serotonin is perhaps most famous for its role in depression.

Serotonin syndrome

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Tricyclic Antidepressants

Tricyclic Antidepressants (TCAs) are so-called because of their molecular structure, which contains three rings of atoms. They act mainly by inhibiting the reuptake of both norepinephrine and serotonin. Other receptors that might also experience a TCA induced inhibition are muscuranic, alpha1 adrenergic, and histaminic receptors.

The TCAs of interest in the treatment of depression include amitriptyline (Elavil, Endep, Tryptanol), amoxapine (Asendin, Asendis, Defanyl, Demolox, Moxadil), clomipramine (Anafranil), imipramine (Tofranil), desipramine (Norpramin, Pertofrane), dothiepin hydrochloride (Thaden, Prothiaden), doxepin (Adapin, Sinequan), Iofepramine (Lomont, Gamanil), triimipramine (Surmontil), nortriptyline (Pamelor, Aventyl), and protriptyline (Vivactil).

Amitriptyline inhibits serotonin and noradrenaline reuptake almost equally. It is approved for the treatment of endogenous depression, involutional melancholia, and reactive depression. Amoxapine mainly inhibits the reuptake of norepinephrine.

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Depression Treatments

Depression is a mental disorder that affects a person’s moods. It affects millions of people around the world. People with depression may feel sad, angry, irritable, tired, confused, guilty, hopeless or worthless. When a person is diagnosed with depression, it’s bad news for himself and his family. It’s painful for the person and can also be difficult for the person’s family. Depression if left untreated could get worse. It will affect a person’s ability to function in daily life and work. Worst still, depression even may lead a person to suicide.

A serious disease depression may be, it is treatable. Proper treatment can help people with depression get back to normal daily activities.

Main treatments for depression are antidepressants and psychotherapy. Antidepressants are medicines that help to relieve depression so that a person suffering from depression can function more normally. There are mainly four types of antidepressants:

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Fibromyalgia Symptoms & Treatment

Symptoms of Fibromyalgia are absolutely diverse and may vary among patients, therefore doctors can never give a universal way of treatment for these kinds of conditions. The best treatment program available for a Fibromyalgia patient is a separate individual program that has been created with the help of a health specialist.

These treatment programs are also best and effective when they are combined with the proper patient education to the condition, regular exercise, stress reduction and medications. Recent studies have shown that there are different positive outcomes whenever one or two of these programs are made in conjunction with another. Let’s try to discuss the important steps in the Fibromyalgia treatment.

Patient Education

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Usual Cures For Persistent Headaches

Chronic headache can turn out to be a major obstacle and may not let perform your daily activities. However, a little time the situation can be severe and prolonged headache may hamper your ordinary life. A person suffering from protracted headaches may be unable to focus for dull hours. Therefore , it becomes imperative that you treat protracted headache before the situation gets out of control. Some of the routine methods of treating chronic headache are noted .

Use of NSAIDs (Non Steroidal Anti-Inflammatory Drugs): These types of drugs are commonly used to treat chronic headache. These are essentially against platelets and inside the brain help in prevention of clumping of platelets, a chief cause of occurrence of migraine. The most often prescribed NSAID prescriptions for treatment of chronic headache include aspirin, amitriptyline plus propranolol, ibuprofen, and valproic acid. Apart from them, there are certain other drugs which can be obtained only through prescription. These include Alpha blockers, Divalproex sodium, Methysergide, Nardil (Phenelzine) and Marplan (isocarboxazid), and Serotonin uptake inhibitors (SSRIs).

A fusion of Acetaminophen with Codeine is yet another common medicine that may be put to use to heal protracted headaches. By essence, codeine is a narcotic pain reliever drug. When codeine is employed together with acetaminophen, the efficiency of the drug is increased and it helps relieve discomfort better. These two drugs may be used to dump both moderate and severe headache forms.

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